Will a full system restore delete malware and other spyware completely?

I have been having issues with malware, possible internet hijacker, and internet trackers on my computer. I have tried using adaware, norman malware cleaner, and my virus scan but nothing will get rid of the problem. I have also ran these programs in safe mode as well and it shows that the malware is deleted, but it comes right back. If I run a full system restore on my computer, will it solve the problem?